Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.

Cell stem cell - 2 Apr 2015

Menon Tushar, Firth Amy L, Scripture-Adams Deirdre D, Galic Zoran, Qualls Susan J, Gilmore William B, Ke Eugene, Singer Oded, Anderson Leif S, Bornzin Alexander R, Alexander Ian E, Zack Jerome A, Verma Inder M

Abstract excerpt

X-linked Severe Combined Immunodeficiency (SCID-X1) is a genetic disease that leaves newborns at high risk of serious infection and a predicted life span of less than 1 year in the absence of a matched bone marrow donor. The disease pathogenesis is due to mutations in the gene encoding the Interleukin-2 receptor gamma chain (IL-2Rγ), leading to a lack of functional lymphocytes. With the leukemogenic concerns of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Enzymes
Share to Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy, Adoptive

Share to Induced Pluripotent Stem Cells

Share to Interleukin Receptor Common gamma Subunit

Share to Killer Cells, Natural

Share to Regeneration

Share to Regenerative Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 25772073
DOI: 10.1016/j.stem.2015.02.005
PMCID: PMC4545662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.PMID 25772073Read ↗

Gene Correction for SCID-X1 in Long-Term Hematopoietic Stem CellsSemantic proximity Read ↗

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.Semantic proximity Read ↗

Gene correction for SCID-X1 in long-term hematopoietic stem cellsSemantic proximity Read ↗

CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cellsSemantic proximity Read ↗

Targeted genome editing in human repopulating haematopoietic stem cells.Semantic proximity Read ↗

Case Report: A Novel IL2RG Frame-Restoring Rescue Mutation Mimics Early T Cell Engraftment Following Haploidentical Hematopoietic Stem Cell Transplantation in a Patient With X-SCID.Semantic proximity Read ↗

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiencySemantic proximity Read ↗

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Semantic proximity Read ↗

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1Semantic proximity Read ↗

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined ImmunodeficiencySemantic proximity Read ↗

Clinical Applications of Gene Therapy for Primary ImmunodeficienciesSemantic proximity Read ↗

Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene TargetingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.