Article
[The role of alphavbeta3 integrin in changes of the invasive phenotype in CP-transformed fibroblasts with multiple drug resistance].
Voprosy meditsinskoi khimii - 1 Jan 2000
Morozevich G E, Kozlova N I, Chubukina A N, Berman A E
Abstract excerpt
A line of Syrian hamster RSV-ransformed fibroblasts having resistance to a number of cytostatics was shown to differ from the parental drug-sensitive line by an extremaly low expression of the integrin alpha v beta 3. In vitro invasive activity of the drug-resistrant cells appeared to be lower than that of their drug-sensitive counterparts. The role of integrin alpha v beta 3 in malignant phenotype and multiple...
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