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Dual Control of Streptokinase and Streptolysin S Production by thecovRSandfasCAXTwo-Component Regulators inStreptococcus dysgalactiaesubsp.equisimilis

1 Jul 2002

Abstract excerpt

Synthesis of the plasminogen activator streptokinase (SK) by group A streptococci (GAS) has recently been shown to be subject to control by two two-component regulators, covRS (or csrRS) and fasBCA. In independent studies, response regulator CovR proved to act as the repressor, whereas FasA was found to act indirectly as the activator by controlling the expression of a stimulatory RNA, fasX. In an attempt at...

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PMID: 12065504
DOI: 10.1128/iai.70.7.3627-3636.2002

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