Article
Substrate specificity of nickel/cobalt permeases: insights from mutants altered in transmembrane domains I and II.
Journal of bacteriology - 1 Jul 2002
Degen Olaf, Eitinger Thomas
Abstract excerpt
HoxN, a high-affinity, nickel-specific permease of Ralstonia eutropha H16, and NhlF, a nickel/cobalt permease of Rhodococcus rhodochrous J1, are structurally related members of the nickel/cobalt transporter (NiCoT) family. These transporters have an eight-helix structure and are characterized by highly conserved segments with polar or charged amino acid residues in transmembrane domains (TMDs) II, III, V, and VI....
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Antiporters
- Asparagine
- Bacterial Proteins
- Base Sequence
- Biological Transport
- Carrier Proteins
- Cation Transport Proteins
- Cell Membrane
- Cobalt
- Histidine
- Membrane Proteins
- Molecular Sequence Data