Article
A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli.
Molecular microbiology - 1 Jul 2003
Woodmansee Anh N, Imlay James A
Abstract excerpt
The presence of nitric oxide (NO) greatly accelerates the rate at which hydrogen peroxide (H2O2) kills Escherichia coli. Workers have suggested that this effect may be important in the process of bacteriocide by phagocytes. The goal of this study was to determine the mechanism of this synergism. The filamentation of the dead cells, and their protection by cell-permeable iron chelators, indicated that NO/H2O2...
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