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Article

A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli.

Molecular microbiology - 1 Jul 2003

Woodmansee Anh N, Imlay James A

Abstract excerpt

The presence of nitric oxide (NO) greatly accelerates the rate at which hydrogen peroxide (H2O2) kills Escherichia coli. Workers have suggested that this effect may be important in the process of bacteriocide by phagocytes. The goal of this study was to determine the mechanism of this synergism. The filamentation of the dead cells, and their protection by cell-permeable iron chelators, indicated that NO/H2O2...

Topics

Bacterial Proteins
DNA Damage
Enzyme Inhibitors
Escherichia coli
FMN Reductase
Hydrazines
Hydro-Lyases
Hydrogen Peroxide
Iron
Mutation
Nitric Oxide
Nitric Oxide Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nitrogen Oxides

Oxidants

Oxidation-Reduction

S-Nitroso-N-Acetylpenicillamine

Source

Identifiers

PMID: 12823807
DOI: 10.1046/j.1365-2958.2003.03530.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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