Article
Genetic association analysis of 5-HT(6) receptor gene polymorphism (267C/T) with tardive dyskinesia.
Psychiatry research - 1 Jun 2002
Ohmori Osamu, Shinkai Takahiro, Hori Hiroko, Nakamura Jun
Abstract excerpt
Possible involvement of serotonergic (5-hydroxytryptamine: 5-HT) receptors in the pathophysiology of tardive dyskinesia (TD) has been suggested. In the present study, the relationship between the 5-HT(6) receptor gene (HTR6) polymorphisms and TD was studied in 173 Japanese patients with schizophrenia. The 267C/T allele of HTR6 was genotyped using PCR amplification followed by endonuclease digestion. The patients...
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