Article
An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005
Nern Aljoscha, Nguyen Louis-Vu T, Herman Tory, Prakash Saurabh, Clandinin Thomas R, Zipursky S Lawrence
Abstract excerpt
Drosophila N-cadherin is required for the formation of precise patterns of connections in the fly brain. Alternative splicing is predicted to give rise to 12 N-cadherin isoforms. We identified an N-cadherin allele, N-cad(18Astop), that eliminates the six isoforms containing alternative exon 18A and demonstrate that it strongly disrupts the connections of R7 photoreceptor neurons. During the first half of pupal...
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