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Article

Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.

Biochemical and biophysical research communications - 14 Jun 2002

Iwahashi Naoko, Murakami Hideki, Nimura Yuji, Takahashi Masahide

Abstract excerpt

Interleukin-8 (IL-8) is known to contribute to human cancer progression through its potential function as a mitogenic, angiogenic, or motogenic factor. We found a high level of IL-8 production in SK-N-MC human primitive neuroectodermal tumor cells transfected with the human RET gene (SK-N-MC (RET) cells) in response to glial cell line-derived neurotrophic factor (GDNF) stimulation. IL-8 was also produced at high...

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Source

Identifiers

PMID: 12056817
DOI: 10.1016/S0006-291X(02)00528-4

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.PMID 12056817Read ↗

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