Article
The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation.
British journal of haematology - 1 Apr 1999
Gattei V, Degan M, Rossi F M, De Iuliis A, Mazzocco F T, Cesa E, Aldinucci D, Zagonel V, Pinto A
Abstract excerpt
The RET gene product represents the signal-transducing molecule of a surface receptor complex for the glial cell line-derived neurotrophic factor (GDNF), which includes GDNFR-alpha as a ligand-binding component. By a semi-quantitative competitive RT-PCR approach, we have analysed the relative abundances of RET transcripts in blasts purified from 40 acute myeloid leukaemia (AML) cases, revealing significant...
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