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Article

Activation of elastin transcription by transforming growth factor-β in human lung fibroblasts

6 Jan 2007

Abstract excerpt

Elastin synthesis is essential for lung development and postnatal maturation as well as for repair following injury. Using human embryonic lung fibroblasts that express undetectable levels of elastin as assessed by Northern analyses, we found that treatment with exogenous transforming growth factor-beta (TGF-beta) induced rapid and transient increases in levels of elastin heterogeneous nuclear RNA (hnRNA)...

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PMID: 17209135
DOI: 10.1152/ajplung.00184.2006

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