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Article

The structure of apo human glutamate dehydrogenase details subunit communication and allostery.

Journal of molecular biology - 3 May 2002

Smith Thomas J, Schmidt Timothy, Fang Jie, Wu Jane, Siuzdak Gary, Stanley Charles A

Abstract excerpt

The structure of human glutamate dehydrogenase (GDH) has been determined in the absence of active site and regulatory ligands. Compared to the structures of bovine GDH that were complexed with coenzyme and substrate, the NAD binding domain is rotated away from the glutamate-binding domain. The electron density of this domain is more disordered the further it is from the pivot helix. Mass spectrometry results...

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Identifiers

PMID: 12054821
DOI: 10.1016/S0022-2836(02)00161-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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