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Article

Proline and lysine residues provide modulatory switches in amyloid formation: Insights from prion protein.

Prion - 1 Jan 2016

Kraus Allison

Abstract excerpt

Amyloidogenic proteins have an increased propensity to reorganize into the highly structured, β sheet rich structures that characterize amyloid. The probability of attaining these highly structured assemblies is influenced by multiple factors, including amino acid composition and environmental conditions. Evolutionary selection for amino acid sequences that prevent amyloid formation could further modulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26864641
DOI: 10.1080/19336896.2015.1132138
PMCID: PMC4981207

Genes

GSS

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