Article
Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity.
Cancer science - 1 Mar 2016
Mori Jinichi, Tanikawa Chizu, Funauchi Yuki, Lo Paulisally Hau Yi, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
In response to various cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes. However, the full picture of the p53 downstream pathway still remains to be elucidated. Here we identified cystatin C, a major inhibitor of cathepsins, as a novel p53 target. In response to DNA damage, activated p53 induced cystatin C expression through p53...
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