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Article

Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Cell death & disease - 1 Jun 2017

Press Eric, Alaga Katanya C, Barr Kevin, Shao Qing, Bosen Felicitas, Willecke Klaus, Laird Dale W

Abstract excerpt

Several mutant mice have been generated to model connexin (Cx)-linked skin diseases; however, the role of connexins in skin maintenance and during wound healing remains to be fully elucidated. Here we generated a novel, viable, and fertile mouse (Cx26CK14-S17F/+) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter. This mutant mouse mirrors several Cx26-linked human skin...

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Identifiers

PMID: 28569788
DOI: 10.1038/cddis.2017.234
PMCID: PMC5520893

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