Article
Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects.
American journal of respiratory and critical care medicine - 15 Nov 2006
Maeda Yukiko, Hizawa Nobuyuki, Jinushi Eisei, Honda Ayumi, Takahashi Daisuke, Fukui Yoshinobu, Konno Satoshi, Shimizu Tadamichi, Shimizu Hiroshi, Yamaguchi Etsuro, Nishimura Masaharu
Abstract excerpt
RATIONALE: The human cholinergic receptor muscarinic-1 (CHRM1) is widely distributed in the lungs. In patients with asthma, CHRM1 may be involved in airway constriction, airway epithelial cell proliferation, and airway inflammation. The CHRM1 gene is located on chromosome 11q13, which is one of the candidate loci for asthma and atopy. OBJECTIVES: To determine the role of the CHRM1 gene polymorphisms in asthma....
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