Article
p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling.
The Journal of clinical investigation - 1 Jun 2002
Sturm Andreas, Itoh Jugoh, Jacobberger James W, Fiocchi Claudio
Abstract excerpt
To mount an effective immune response, T cells must divide in response to antigen contact. To maintain tolerance, mucosal lamina propria T cells (LPTs) may adapt their cycling to an antigen-rich gut stimulatory environment. Here, we compared the cell cycle kinetics of LPTs and peripheral blood T cells (PBTs) before and after CD3- and CD2-mediated activation. While CD3-activated naive (CD45RA(+)) and memory...
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