Interaction of Two Actin-binding Proteins, Synaptopodin and α-Actinin-4, with the Tight Junction Protein MAGI-1

Abstract excerpt

In an attempt to find podocyte-expressed proteins that may interact with the tight junction protein MAGI-1, we screened a glomerulus-enriched cDNA library with a probe consisting of both WW domains of MAGI-1. One of the isolated clones contained two WW domain-binding motifs and was identified as a portion of the actin-bundling protein synaptopodin. In vitro binding assays confirmed this interaction between MAGI-1...

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