Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.

doi:10.1038/sj.gt.3300966

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Article

Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.

Gene therapy - 1 Aug 1999

Kokoris M S, Sabo P, Adman E T, Black M E

Abstract excerpt

With the advent of gene therapy, herpes simplex virus type I (HSV-1) thymidine kinase (TK) has garnered much interest as a suicide gene for cancer ablation. As a means to improve the overall efficacy of the prodrug-gene activation approach, as well as to reduce ganciclovir-mediated toxicity, a large library of mutant thymidine kinases was generated and screened for the ability to enhance in vitro cell sensitivity...

Topics

Acyclovir
Amino Acid Sequence
Animals
Ganciclovir
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors
Glioma
Herpesvirus 1, Human
Mice
Mice, Nude
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Neoplasm Transplantation

Prodrugs

Rats

Thymidine Kinase

Source

Open in PubMed

Identifiers

PMID: 10467366
DOI: 10.1038/sj.gt.3300966

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