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Article

Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.

Gene therapy - 1 Aug 1999

Kokoris M S, Sabo P, Adman E T, Black M E

Abstract excerpt

With the advent of gene therapy, herpes simplex virus type I (HSV-1) thymidine kinase (TK) has garnered much interest as a suicide gene for cancer ablation. As a means to improve the overall efficacy of the prodrug-gene activation approach, as well as to reduce ganciclovir-mediated toxicity, a large library of mutant thymidine kinases was generated and screened for the ability to enhance in vitro cell sensitivity...

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Source

Identifiers

PMID: 10467366
DOI: 10.1038/sj.gt.3300966

Genes

C6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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