Article
Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells.
Circulation research - 12 Nov 1999
Engelse M A, Neele J M, van Achterberg T A, van Aken B E, van Schaik R H, Pannekoek H, de Vries C J
Abstract excerpt
Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression of human atherosclerosis. The expression of activin, its physiological inhibitor follistatin, and activin receptors were assayed in human vascular tissue specimens that...
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