Article
The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder.
Human immunology - 1 Apr 2002
Torres Anthony R, Maciulis Alma, Stubbs E Gene, Cutler Adele, Odell Dennis
Abstract excerpt
We have evaluated possible contributions of HLA-DRB1 alleles to autism spectrum disorder (ASD) in 103 families of Caucasian descent. The DR4 allele occurred more often in probands than controls (0.007), whereas the DR13,14 alleles occurred less often in probands than controls (p = 0.003). The transmission disequilibrium test (TDT) indicated that the ASD probands inherited the DR4 allele more frequently than...
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