Article
Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin.
The Journal of biological chemistry - 15 Oct 1992
Randi A M, Jorieux S, Tuley E A, Mazurier C, Sadler J E
Abstract excerpt
von Willebrand factor (vWF) is a multimeric plasma glycoprotein that mediates platelet adhesion to the subendothelium via binding to platelet glycoprotein Ib (GPIb) and to components of the vessel wall. Recently, missense mutations that cause type IIB von Willebrand disease (vWD) were described,...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Cell Line
- Chromatography, Affinity
- Cloning, Molecular
- Collagen
- Glutamine
- Heparin
- Humans
- Kinetics
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Plasmids
- Recombinant Proteins