Article
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
Oncogene - 13 Jun 2002
Shin Min Sun, Kim Hong Sug, Lee Sug Hyung, Lee Jong Woo, Song Young Hwa, Kim Young Sill, Park Won Sang, Kim Su Young, Lee Shi Nae, Park Jik Young, Lee Jong Heun, Xiao Wensua, Jo Keon Hyon, Wang Young Pil, Lee Kyo Young, Park Yong Gyu, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin
Abstract excerpt
Many types of cancer cells are resistant to Fas-mediated apoptosis by several mechanisms, including the mutations of the genes involved in Fas-mediated apoptosis. In this study, to explore the possibility that the mutations of the genes involved in the proximal pathway of Fas-mediated apoptosis (Fas, FADD, caspase 8 and caspase 10) are involved in cancer metastasis, we have analysed somatic mutation and deletion...
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