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Article

Effects of tyrosine hydroxylase mutants on locomotor activity in Drosophila: a study in functional genomics.

Behavior genetics - 1 Mar 2002

Pendleton Robert G, Rasheed Aseel, Sardina Thomas, Tully Tim, Hillman Ralph

Abstract excerpt

The brain of the adult fruit fly, Drosophila melanogaster, contains tyrosine hydroxylase, the rate-limiting enzyme required for catecholamine biosynthesis, as well as dopa decarboxylase. Catecholamines, principally dopamine, are also present. We have previously shown that pharmacological inhibition of tyrosine hydroxylase with alpha-methyl-p-tyrosine results in a dose-related inhibition of locomotor activity in...

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PMID: 12036114
DOI: 10.1023/a:1015279221600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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