Article
GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.
The Journal of biological chemistry - 9 Aug 2002
Mao Qingcheng, Qiu Wei, Weigl Kevin E, Lander Peter A, Tabas Linda B, Shepard Robert L, Dantzig Anne H, Deeley Roger G, Cole Susan P C
Abstract excerpt
Substrates transported by the 190-kDa multidrug resistance protein 1 (MRP1) (ABCC1) include endogenous organic anions such as the cysteinyl leukotriene C(4). In addition, MRP1 confers resistance against various anticancer drugs by reducing intracellular accumulation by co-export of drug with reduced GSH. We have examined the properties of LY475776, an intrinsically photoactivable MRP1-specific tricyclic isoxazole...
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