Article
PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1994
Chen Z, Guidez F, Rousselot P, Agadir A, Chen S J, Wang Z Y, Degos L, Zelent A, Waxman S, Chomienne C
Abstract excerpt
Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric pr...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 17
- Cloning, Molecular
- Genetic Variation
- Haplorhini
- Humans
- Leukemia, Promyelocytic, Acute
- Molecular Sequence Data
- Neoplasm Proteins
- Receptors, Retinoic Acid