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Article

Regulation of MAPK function by direct interaction with the mating-specific Galpha in yeast.

Science (New York, N.Y.) - 24 May 2002

Metodiev Metodi V, Matheos Dina, Rose Mark D, Stone David E

Abstract excerpt

The mating response of the budding yeast Saccharomyces cerevisiae is mediated by a prototypical heterotrimeric GTP-binding protein (G protein) and mitogen-activated protein kinase (MAPK) cascade. Although signal transmission by such pathways has been modeled in detail, postreceptor down-regulation is less well understood. The pheromone-responsive G protein alpha subunit (Galpha) of yeast down-regulates the mating...

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Source

Identifiers

PMID: 12029138
DOI: 10.1126/science.1070540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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