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Article

Localization of heparanase in normal and pathological human placenta

1 Jun 2002

Abstract excerpt

Degradation of extracellular matrix (ECM) components is critical for invasion. Heparan sulphate proteoglycans are abundant in the ECM of the placenta and the decidua, hence their degradation may disassemble the matrix and facilitate placentation and trophoblast invasion. This study investigates the expression of heparanase in normal and pathological placentation using RT-PCR, in-situ hybridization and...

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PMID: 12029075
DOI: 10.1093/molehr/8.6.566

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