Article
Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Developmental biology - 15 Feb 2004
Leach Richard E, Kilburn Brian, Wang Jun, Liu Zitao, Romero Roberto, Armant D Randall
Abstract excerpt
Cytotrophoblasts of the anchoring villi convert during human placentation from a transporting epithelium to an invasive, extravillous phenotype that expresses a distinct repertoire of adhesion molecules. Developing extravillous trophoblasts accumulate heparin-binding EGF-like growth factor (HB-EGF), a multifunctional cytokine, which binds HER1 and HER4 of the human EGF receptor (HER/ErbB) family. HB-EGF is...
Topics
- Animals
- Cell Adhesion
- Cell Division
- Cell Line
- Cell Movement
- Chorionic Villi
- Culture Techniques
- Epidermal Growth Factor
- ErbB Receptors
- Female
- Growth Substances
- Heparin-binding EGF-like Growth Factor
- Humans