Article
Endoglin Regulates Trophoblast Differentiation along the Invasive Pathway in Human Placental Villous Explants*
1 Nov 1997
Abstract excerpt
Successful invasion of the maternal vascular system by trophoblast cells is a prerequisite for the establishment of a normal hemochorial placenta. Transforming growth factor-beta (TGFbeta) has been implicated in the regulation of trophoblast invasiveness into the uterus. Endoglin is a component of the TGFbeta receptor complex that binds beta1 and beta3 isoforms and is expressed at high levels on...