Article
Association and linkage analyses of RGS4 polymorphisms in schizophrenia.
Human molecular genetics - 1 Jun 2002
Chowdari Kodavali V, Mirnics Karoly, Semwal Prachi, Wood Joel, Lawrence Elizabeth, Bhatia Triptish, Deshpande Smita N, B K Thelma, Ferrell Robert E, Middleton Frank A, Devlin Bernie, Levitt Pat, Lewis David A, Nimgaonkar Vishwajit L
Abstract excerpt
Gene expression analyses of postmortem cerebral cortex suggest that transcription of the regulator of G-protein signaling 4 (RGS4) is decreased in a diagnosis-specific manner in subjects with schizophrenia. To evaluate the possible role of RGS4 in the pathogenesis of schizophrenia, we conducted genetic association and linkage studies using samples ascertained independently in Pittsburgh and New Delhi and by the...
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