Article
The role of passenger leukocyte genotype in rejection and acceptance of rat liver allografts.
Transplantation - 15 May 2002
Kreisel Daniel, Petrowsky Henrik, Krasinskas Alyssa M, Krupnick Alexander S, Szeto Wilson Y, McLean Andrew D, Popma Sicco H, Gelman Andrew E, Traum Marcy K, Furth Emma E, Moore Jonni S, Rosengard Bruce R
Abstract excerpt
BACKGROUND: Although graft-resident passenger leukocytes are known to mediate acute rejection by triggering direct allorecognition, they may also act in an immunomodulatory fashion and play an important role in tolerance induction. Our purpose in the current study was to utilize rat bone marrow chimeras to evaluate the role of the genotype of passenger leukocytes in both acute rejection and tolerance of liver...
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