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Acquired Carbapenem-Hydrolyzing Beta-Lactamases and their Genetic Support

1 Jun 2002

Abstract excerpt

Carbapenem-hydrolyzing beta-lactamases of several Ambler molecular classes have been reported as the source of acquired beta-lactam antibiotic resistance in Gram negative bacteria. The metallo-enzymes of Ambler class B are the most prevalent enzymes in this case. These clavulanic-acid resistant enzymes have a large spectrum of hydrolysis including penicillins, cephalosporins (third and fourth generations),...

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PMID: 12022255
DOI: 10.2174/1389201023378427

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