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Carbapenemases: Molecular Diversity and Clinical Consequences

1 Oct 2007

Abstract excerpt

Carbapenemases are beta-lactamases that hydrolyze most beta-lactams including carbapenems. Carbapenemases are classified in four molecular classes; those belonging to class A are the chromosomally-encoded and clavulanic acid-inhibited IMI, NMC-A and SME, identified in Enterobacter cloacae and Serratia marcescens; the plasmid-encoded KPC enzymes identified in Enterobacteriaceae (and rarely in Pseudomonas...

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PMID: 17927473
DOI: 10.2217/17460913.2.5.501

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