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Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives

27 May 2023

Abstract excerpt

Human deaths caused by Gram-negative bacteria keep rising due to the multidrug resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with different mechanisms of action. Several bacterial zinc metalloenzymes are becoming attractive targets since they do not show any similarities with the human endogenous zinc-metalloproteinases. In the last decades, there has been an increasing...

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PMID: 37298854
DOI: 10.3390/molecules28114378

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