Article
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
Development (Cambridge, England) - 1 Jun 2002
Katz Jonathan P, Perreault Nathalie, Goldstein Bree G, Lee Catherine S, Labosky Patricia A, Yang Vincent W, Kaestner Klaus H
Abstract excerpt
Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that Klf4 plays an important role in cell proliferation and/or differentiation. Mice homozygous for a null mutation in Klf4 die within 15 hours of birth and show selective perturbation of late-stage differentiation structures in...
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