Article
Structural basis for oseltamivir resistance of influenza viruses.
Vaccine - 23 Oct 2009
Collins P J, Haire L F, Lin Y P, Liu J, Russell R J, Walker P A, Martin S R, Daniels R S, Gregory V, Skehel J J, Gamblin S J, Hay A J
Abstract excerpt
Oseltamivir, one of the two anti-neuraminidase drugs, is currently the most widely used drug against influenza. Resistance to the drug has occurred infrequently among different viruses in response to drug treatment, including A H5N1 viruses, but most notably has emerged among recently circulating A H1N1 viruses and has spread throughout the population in the absence of drug use. Crystal structures of enzyme-drug...
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