Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2002

Harstad Eric B, Klaassen Curtis D

Abstract excerpt

Acute administration of cadmium (Cd) in rats results in hepatotoxicity that appears to involve the activation of Kupffer cells and the subsequent production of proinflammatory chemokines and cytokines. However, the importance of these endogenous mediators in Cd-induced hepatotoxicity is unknown. Therefore, this study was conducted to define and utilize a rat strain difference in sensitivity to Cd-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadmium
Share to Chemokines
Share to Cytokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Environmental Pollutants

Share to Injections, Intravenous

Share to Oligonucleotide Probes

Share to Rats, Inbred F344

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 12011493
DOI: 10.1093/toxsci/67.2.329

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.PMID 12011493Read ↗

Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses.Semantic proximity Read ↗

Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).Semantic proximity Read ↗

Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains.Semantic proximity Read ↗

Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice.Semantic proximity Read ↗

Differences in the response to oxidative stress and mutant frequency in CD (Sprague-Dawley) and Fisher 344 rats due to an induced inflammatory response.Semantic proximity Read ↗

Genome-linked toxic responses to dietary iron overload.Semantic proximity Read ↗

Impact of cadmium in T lymphocyte subsets and cytokine expression: differential regulation by oxidative stress and apoptosis.Semantic proximity Read ↗

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.Semantic proximity Read ↗

Sex- and strain-specific expression of cytochrome P450s in Ochratoxin A-induced genotoxicity and carcinogenicity in ratsSemantic proximity Read ↗

Strain differences in haematological response to chloramphenicol succinate in mice: implications for toxicological research.Semantic proximity Read ↗

Dose-response analysis of short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in three differentially susceptible rat lines.Semantic proximity Read ↗

Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.