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DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes

2 Sept 2003

Abstract excerpt

For the success of fertilization, spindles of vertebrate oocytes must remain stable and correctly organized during the arrest in metaphase II of meiosis. Using a two-hybrid screen with MAPK as a bait, we have recently identified MISS (MAPK interacting and spindle stabilizing) which controls mouse oocyte metaphase II spindle stability. Using the same screen, we identify another MAPK partner, DOC1R (Deleted in oral...

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PMID: 12944431
DOI: 10.1242/dev.00731

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