Article
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.
Pharmacogenetics and genomics - 1 Feb 2007
Kurkela Mika, Patana Anne-Sisko, Mackenzie Peter I, Court Michael H, Tate Christopher G, Hirvonen Jouni, Goldman Adrian, Finel Moshe
Abstract excerpt
OBJECTIVES: To explore the possible role of hetero-oligomerization among the human UDP-glucuronosyltransferases in attenuating the consequences of the pathological Y486D mutation (UGT1A1 numbering) that often causes hyperbilirubinaemia. Owing to exon sharing in the human UGT1A gene, the equivalent mutation is present in all other UGT1As of the affected individuals. It is unknown, however, if this mutation results...
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