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Article

Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase.

European journal of biochemistry - 1 Feb 1999

Tinguely J N, Wermuth B

Abstract excerpt

Carbonyl reductase is highly susceptible to inactivation by organomercurials suggesting the presence of a reactive cysteine residue in, or close to, the active site. This residue is also close to a site which binds glutathione. Structurally, carbonyl reductase belongs to the short-chain dehydrogenase/reductase family and contains five cysteine residues, none of which is conserved within the family. In order to...

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Identifiers

PMID: 10091578
DOI: 10.1046/j.1432-1327.1999.00089.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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