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Article

Minihelix-loop RNAs: minimal structures for aminoacylation catalysts.

Nucleic acids research - 15 May 2002

Ramaswamy Krishna, Wei Kenneth, Suga Hiroaki

Abstract excerpt

We report here an in vitro selected ribozyme, KL17, which is active in charging amino acids on its own 5'-OH group. The ribozyme consists of two catalytic domains, one of which (consisting of P5/P6/L6) recognizes amino acid substrates based on the steric environment of the side chain, whereas the other recognizes an aminoacylated oligonucleotide. The secondary structure of this ambidextrous ribozyme arranges into...

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Identifiers

PMID: 12000836
DOI: 10.1093/nar/30.10.2162
PMCID: PMC115283

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Source receipt: pubmed, retrieved 7 Sept 2026.

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