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Article

p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax.

International journal of oncology - 1 Nov 2013

Kim Chae Won, Lu Jing Nan, Go Se-Il, Jung Ji Hyun, Yi Sang Mi, Jeong Jae-Hoon, Hah Young-Sool, Han Myung Shin, Park Jeong Woo, Lee Won Sup, Min Young Joo

Abstract excerpt

Cisplatin (CDDP) is a chemotherapeutic agent that is widely used to treat many cancers. However, initial resistance to CDDP is a serious problem in treating cancers. In this study, in order to develop an approach to overcome resistance to CDDP, we investigated the difference in apoptotic processes between CDDP-sensitive cells and CDDP-resistant cells. By screening with CDDP sensitivity tests, we chose SNU-16...

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Share to bcl-2-Associated X Protein
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Immunoenzyme Techniques

Share to Membrane Potential, Mitochondrial

Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 23970333
DOI: 10.3892/ijo.2013.2070

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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