Article
Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas.
Cancer genetics and cytogenetics - 1 Apr 2002
Hemmer Samuli, Wasenius Veli Matti, Haglund Caj, Zhu Ying, Knuutila Sakari, Franssila Kaarle, Joensuu Heikki
Abstract excerpt
Deletion of chromosome 11q23 is a common alteration in parathyroid adenomas and hyperplasias. A new potential suppressor gene PPP2R1B encoding the beta isoform of the A subunit of the serine/threorine protein phosphatase 2A was recently identified and localized to chromosome 11q23. We performed polymerase chain reaction-based single-strand conformation polymorphism and direct sequencing on six parathyroid...
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