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Article

Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors.

International journal of cancer - 1 Jun 2002

Schelwies Katharina, Sturm Isrid, Grabowski Patricia, Scherübl Hans, Schindler Isabell, Hermann Sandra, Stein Harald, Buhr Heinz-Johannes, Riecken Ernst O, Zeitz Martin, Dörken Bernd, Daniel Peter T

Abstract excerpt

Deregulation of cell death pathways contributes to tumor development and to the clinical course of cancer disease. In patients with liver metastases of colorectal cancer, we have previously shown that an intact p53/BAX apoptotic pathway is a positive prognostic factor. Therefore, the purpose of our study was to determine the prognostic value of BAX protein expression and the mutational status of its upstream...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11992551
DOI: 10.1002/ijc.10380

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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