Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines.

doi:10.1038/sj.onc.1204343

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Article

Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines.

Oncogene - 17 May 2001

Bentires-Alj M, Dejardin E, Viatour P, Van Lint C, Froesch B, Reed J C, Merville M P, Bours V

Abstract excerpt

The NF-kappa B transcription factor has been shown to inhibit apoptosis in several experimental systems. We therefore investigated whether the expression of the Bax proapoptotic protein could be influenced by NF-kappa B activity. Increased Bax protein expression was detected in HCT116, OVCAR-3 and MCF7 cells stably expressing a mutated unresponsive I kappa B-alpha inhibitory protein that blocks NF-kappa B...

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PMID: 11420692
DOI: 10.1038/sj.onc.1204343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.