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Article

The sortase A substrates FnbpA, FnbpB, ClfA and ClfB antagonize colony spreading of Staphylococcus aureus.

PloS one - 1 Jan 2012

Tsompanidou Eleni, Denham Emma L, Sibbald Mark J J B, Yang Xiao-Mei, Seinen Jolien, Friedrich Alexander W, Buist Girbe, van Dijl Jan Maarten

Abstract excerpt

Staphylococcus aureus is an important human pathogen that is renowned both for its rapid transmission within hospitals and the community, and for the formation of antibiotic resistant biofilms on medical implants. Recently, it was shown that S. aureus is able to spread over wet surfaces. This motility phenomenon is promoted by the surfactant properties of secreted phenol-soluble modulins (PSMs), which are also...

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PMID: 22970276
DOI: 10.1371/journal.pone.0044646
PMCID: PMC3436756

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