Testing two possible mechanisms for gametic association in human: frozen haplotypes and segregation distortion.

Abstract excerpt

Two possible mechanisms for the development and maintenance of gametic association have been subject to test using family studies (HLA typed) and direct analysis of two linked markers in individual sperm. The mechanisms are: (I) haplotypes frozen against recombination and (2) balanced segregation distortion. In the study of 1,320 families, 86 individuals were identified in the offspring of whom recombination was...

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