Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus.

Article

Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus.

American journal of human genetics - 1 Oct 1996

Leeflang E P, McPeek M S, Arnheim N

Abstract excerpt

Meiotic drive at the myotonic dystrophy (DM) locus has recently been suggested as being responsible for maintaining the frequency, in the human population, of DM chromosomes capable of expansion to the disease state. In order to test this hypothesis, we have studied samples of single sperm from t...

Topics

Adult
Alleles
Genetic Carrier Screening
Humans
Male
Meiosis
Models, Biological
Myotonic Dystrophy
Polymerase Chain Reaction
Spermatozoa

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