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Article

Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae.

Microbiology (Reading, England) - 1 May 2002

Riffer Frank, Eisfeld Katrin, Breinig Frank, Schmitt Manfred J

Abstract excerpt

K28 killer strains of Saccharomyces cerevisiae are permanently infected with a cytoplasmic persisting dsRNA virus encoding a secreted alpha/beta heterodimeric protein toxin that kills sensitive cells by cell-cycle arrest and inhibition of DNA synthesis. In vivo processing of the 345 aa toxin precursor (preprotoxin; pptox) involves multiple internal and carboxy-terminal cleavage events by the prohormone...

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PMID: 11988505
DOI: 10.1099/00221287-148-5-1317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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