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Article

A highly conserved tryptophane residue indispensable for cloned rat neuronal P2X receptor activation.

Neuroscience letters - 17 May 2002

Nakazawa Ken, Ojima Hiloe, Ohno Yasuo

Abstract excerpt

The role of a tryptophane residue (Trp(256)) in the extracellular loop of a neuronal P2X receptor clone (P2X(2) receptor/channel) was investigated using site-directed mutagenesis and Xenopus oocyte expression. When Trp(256) was replaced with leucine, serine or phenylalanine (W256L, W256S or W256F), a current response to adenosine triphosphate (ATP) mediated through the P2X2 receptor/channel was abolished. When...

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Identifiers

PMID: 11988347
DOI: 10.1016/s0304-3940(02)00234-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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